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Averagebone-to-plasma AUC ratios for teicoplanin were 0.12 for cortical (n=17 patients) and0.56 for cancellous bone (n=15). Risk of osteoporosis after pro-longed use is also minimal. Orthotopic neobladder substitution hasemerged as a gold standard after radical cystectomy for bladder cancer and has acceptablecomplication rates in properly selected patients.
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